Alaska Airlines flight AS 4378: Multiple routes

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FLIGHT SCHEDULE
Direct Codeshare Flights:
Mon,Tue,Sat,Sun 06:00 El Paso (ELP) 10:14 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 175 (E75) 3:14 Effective 2025-08-02 through 2025-08-05
Codeshare flight, operated by American Airlines.(AA 3484)
Daily 06:16 Moline (MLI) 07:30 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:14 Effective 2025-11-02 through 2025-12-02
Codeshare flight, operated by American Airlines.(AA 3507)
Daily 06:50 Chicago O'Hare (ORD) 3 09:37 George Bush, Houston (IAH) A
AS 4378 Non-stop Airbus A319 (319) 2:47 Effective 2025-05-05 through 2025-06-04
Codeshare flight, operated by American Airlines.(AA 2365)
Thu,Sun 07:15 Phoenix Sky Harbor (PHX) 4 09:21 Sacramento (SMF) A
AS 4378 Non-stop Canadair CRJ 700 (CR7) 2:06 Effective 2025-06-05 through 2025-06-08
Codeshare flight, operated by American Airlines.(AA 6245)
Sun 07:17 Chicago O'Hare (ORD) 3 09:51 Pittsburgh (PIT)
AS 4378 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2025-06-15 through 2025-06-29
Codeshare flight, operated by American Airlines.(AA 4299)
Mon,Thu 07:17 Chicago O'Hare (ORD) 3 09:51 Pittsburgh (PIT)
AS 4378 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2025-06-30 through 2025-07-03
Codeshare flight, operated by American Airlines.(AA 4299)
Daily 07:20 Kansas City (MCI) 09:10 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Canadair CRJ 700 (CR7) 1:50 Effective 2026-01-08 through 2026-02-11
Codeshare flight, operated by American Airlines.(AA 6245)
Daily 07:46 Oklahoma City (OKC) 09:15 Los Angeles (LAX)
AS 4378 Non-stop Embraer EMB 175 (E75) 3:29 Effective 2025-12-18 through 2026-01-05
Codeshare flight, operated by American Airlines.(AA 6462)
Tue 08:00 Oklahoma City (OKC) 09:26 Los Angeles (LAX)
AS 4378 Non-stop Embraer EMB 175 (E75) 3:26 Operates only on 2026-01-06
Codeshare flight, operated by American Airlines.(AA 6462)
Mon-Fri,Sun 08:02 Los Angeles (LAX) 11:06 El Paso (ELP)
AS 4378 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2025-08-10 through 2025-08-19
Codeshare flight, operated by American Airlines.(AA 6522)
Sat 08:02 Los Angeles (LAX) 11:06 El Paso (ELP)
AS 4378 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2025-08-23 through 2025-08-30
Codeshare flight, operated by American Airlines.(AA 6522)
Mon-Fri,Sun 08:17 Philadelphia (PHL) 09:55 Memphis (MEM)
AS 4378 Non-stop Embraer EMB 175 (E75) 2:38 Effective 2025-07-06 through 2025-07-11
Codeshare flight, operated by American Airlines.(AA 4450)
Wed 08:20 Philadelphia (PHL) 10:21 Charleston (CHS)
AS 4378 Non-stop Airbus A319 (319) 2:01 Operates only on 2026-01-07
Codeshare flight, operated by American Airlines.(AA 2365)
Daily 08:32 Flagstaff Pulliam, Grand Canyon (FLG) 09:39 Phoenix Sky Harbor (PHX) 4
AS 4378 Non-stop Canadair CRJ 700 (CR7) 1:07 Effective 2025-10-06 through 2025-11-01
Codeshare flight, operated by American Airlines.(AA 6441)
Daily 08:39 Flagstaff Pulliam, Grand Canyon (FLG) 09:39 Phoenix Sky Harbor (PHX) 4
AS 4378 Non-stop Canadair CRJ 700 (CR7) 1:00 Effective 2025-09-03 through 2025-10-05
Codeshare flight, operated by American Airlines.(AA 6441)
Thu,Sun 09:51 Sacramento (SMF) A 11:52 Phoenix Sky Harbor (PHX) 4
AS 4378 Non-stop Canadair CRJ 700 (CR7) 2:01 Effective 2025-06-05 through 2025-06-08
Codeshare flight, operated by American Airlines.(AA 6245)
Sun 11:35 Pittsburgh (PIT) 12:21 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 175 (E75) 1:46 Effective 2025-06-15 through 2025-06-29
Codeshare flight, operated by American Airlines.(AA 4299)
Mon,Thu 11:35 Pittsburgh (PIT) 12:21 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 175 (E75) 1:46 Effective 2025-06-30 through 2025-07-03
Codeshare flight, operated by American Airlines.(AA 4299)
Sat 12:10 Syracuse (SYR) 13:36 Ronald Reagan Washington (DCA) 2
AS 4378 Non-stop Embraer EMB 175 (E75) 1:26 Effective 2025-07-05 through 2025-07-26
Codeshare flight, operated by American Airlines.(AA 4367)
Mon-Fri,Sun 13:05 Memphis (MEM) 16:35 Philadelphia (PHL) F
AS 4378 Non-stop Canadair CRJ 900 (CR9) 2:30 Effective 2025-07-13 through 2025-08-01
Codeshare flight, operated by American Airlines.(AA 5040)
Fri 13:10 Pittsburgh (PIT) 13:55 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 175 (E75) 1:45 Operates only on 2025-07-04
Codeshare flight, operated by American Airlines.(AA 4299)
Daily 13:29 George Bush, Houston (IAH) A 16:12 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Airbus A319 (319) 2:43 Effective 2025-05-05 through 2025-06-04
Codeshare flight, operated by American Airlines.(AA 2365)
Sat 14:21 Charleston (CHS) 16:00 Ronald Reagan Washington (DCA) 2
AS 4378 Non-stop Canadair CRJ 900 (CR9) 1:39 Effective 2025-06-07 through 2025-06-28
Codeshare flight, operated by American Airlines.(AA 5607)
Daily 15:09 Knoxville (TYS) 16:16 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer ERJ 145 (ER4) 2:07 Valid until 2025-05-04
Codeshare flight, operated by American Airlines.(AA 5722)
Fri 15:40 Pittsburgh (PIT) 17:50 Dallas Fort Worth (DFW)
AS 4378 Non-stop Embraer EMB 175 (E75) 3:10 Operates only on 2025-06-06
Codeshare flight, operated by American Airlines.(AA 3961)
Wed-Fri 15:56 Fayetteville/Springdale (XNA) 17:35 Los Angeles (LAX)
AS 4378 Non-stop Embraer EMB 175 (E75) 3:39 Effective 2025-08-06 through 2025-08-08
Codeshare flight, operated by American Airlines.(AA 6386)
Daily 16:01 Grand Rapids (GRR) 16:10 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Canadair CRJ 700 (CR7) 1:09 Effective from 2026-02-12
Codeshare flight, operated by American Airlines.(AA 6245)
Mon-Fri 16:43 Richmond (RIC) 17:53 Philadelphia (PHL) F
AS 4378 Non-stop Canadair CRJ 900 (CR9) 1:10 Effective 2025-06-09 through 2025-06-27
Codeshare flight, operated by American Airlines.(AA 5604)
Wed 16:43 Richmond (RIC) 17:53 Philadelphia (PHL) F
AS 4378 Non-stop Canadair CRJ 900 (CR9) 1:10 Operates only on 2025-07-02
Codeshare flight, operated by American Airlines.(AA 5604)
Daily 19:23 John Glenn Columbus (CMH) 19:50 Chicago O'Hare (ORD) 3
AS 4378 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:27 Effective 2025-12-03 through 2025-12-17
Codeshare flight, operated by American Airlines.(AA 4299)
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This flight number is listed as serving the following routes:


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Alaska Airlines flight AS 4378: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Alaska Airlines AS4378
06:00
El Paso (ELP)

10:14
Chicago O'Hare (ORD) 3
Effective 2025-08-02 through 2025-08-05
Mon
Tue
Wed
-
Thu
-
Fri
-
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3484)
Duration: 3:14, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
06:16
Moline (MLI)

07:30
Chicago O'Hare (ORD) 3
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3507)
Duration: 1:14, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4378
06:50
Chicago O'Hare (ORD) 3

09:37
George Bush, Houston (IAH) A
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 2365)
Duration: 2:47, non-stop
Airbus A319 (319)
Alaska Airlines AS4378
07:15
Phoenix Sky Harbor (PHX) 4

09:21
Sacramento (SMF) A
Effective 2025-06-05 through 2025-06-08
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 6245)
Duration: 2:06, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
07:17
Chicago O'Hare (ORD) 3

09:51
Pittsburgh (PIT)
Effective 2025-06-15 through 2025-06-29
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
07:17
Chicago O'Hare (ORD) 3

09:51
Pittsburgh (PIT)
Effective 2025-06-30 through 2025-07-03
Mon
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
07:20
Kansas City (MCI)

09:10
Chicago O'Hare (ORD) 3
Effective 2026-01-08 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6245)
Duration: 1:50, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
07:46
Oklahoma City (OKC)

09:15
Los Angeles (LAX)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6462)
Duration: 3:29, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
08:00
Oklahoma City (OKC)

09:26
Los Angeles (LAX)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 6462)
Duration: 3:26, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
08:02
Los Angeles (LAX)

11:06
El Paso (ELP)
Effective 2025-08-10 through 2025-08-19
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 6522)
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
08:02
Los Angeles (LAX)

11:06
El Paso (ELP)
Effective 2025-08-23 through 2025-08-30
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 6522)
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
08:17
Philadelphia (PHL)

09:55
Memphis (MEM)
Effective 2025-07-06 through 2025-07-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4450)
Duration: 2:38, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
08:20
Philadelphia (PHL)

10:21
Charleston (CHS)
Operates only on 2026-01-07
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 2365)
Duration: 2:01, non-stop
Airbus A319 (319)
Alaska Airlines AS4378
08:32
Flagstaff Pulliam, Grand Canyon (FLG)

09:39
Phoenix Sky Harbor (PHX) 4
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6441)
Duration: 1:07, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
08:39
Flagstaff Pulliam, Grand Canyon (FLG)

09:39
Phoenix Sky Harbor (PHX) 4
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6441)
Duration: 1:00, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
09:51
Sacramento (SMF) A

11:52
Phoenix Sky Harbor (PHX) 4
Effective 2025-06-05 through 2025-06-08
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 6245)
Duration: 2:01, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
11:35
Pittsburgh (PIT)

12:21
Chicago O'Hare (ORD) 3
Effective 2025-06-15 through 2025-06-29
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:46, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
11:35
Pittsburgh (PIT)

12:21
Chicago O'Hare (ORD) 3
Effective 2025-06-30 through 2025-07-03
Mon
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:46, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
12:10
Syracuse (SYR)

13:36
Ronald Reagan Washington (DCA) 2
Effective 2025-07-05 through 2025-07-26
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 4367)
Duration: 1:26, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
13:05
Memphis (MEM)

16:35
Philadelphia (PHL) F
Effective 2025-07-13 through 2025-08-01
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 5040)
Duration: 2:30, non-stop
Canadair CRJ 900 (CR9)
Alaska Airlines AS4378
13:10
Pittsburgh (PIT)

13:55
Chicago O'Hare (ORD) 3
Operates only on 2025-07-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
13:29
George Bush, Houston (IAH) A

16:12
Chicago O'Hare (ORD) 3
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 2365)
Duration: 2:43, non-stop
Airbus A319 (319)
Alaska Airlines AS4378
14:21
Charleston (CHS)

16:00
Ronald Reagan Washington (DCA) 2
Effective 2025-06-07 through 2025-06-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 5607)
Duration: 1:39, non-stop
Canadair CRJ 900 (CR9)
Alaska Airlines AS4378
15:09
Knoxville (TYS)

16:16
Chicago O'Hare (ORD) 3
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5722)
Duration: 2:07, non-stop
Embraer ERJ 145 (ER4)
Alaska Airlines AS4378
15:40
Pittsburgh (PIT)

17:50
Dallas Fort Worth (DFW)
Operates only on 2025-06-06
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 3961)
Duration: 3:10, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
15:56
Fayetteville/Springdale (XNA)

17:35
Los Angeles (LAX)
Effective 2025-08-06 through 2025-08-08
Mon
-
Tue
-
Wed
Thu
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 6386)
Duration: 3:39, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4378
16:01
Grand Rapids (GRR)

16:10
Chicago O'Hare (ORD) 3
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6245)
Duration: 1:09, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4378
16:43
Richmond (RIC)

17:53
Philadelphia (PHL) F
Effective 2025-06-09 through 2025-06-27
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5604)
Duration: 1:10, non-stop
Canadair CRJ 900 (CR9)
Alaska Airlines AS4378
16:43
Richmond (RIC)

17:53
Philadelphia (PHL) F
Operates only on 2025-07-02
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5604)
Duration: 1:10, non-stop
Canadair CRJ 900 (CR9)
Alaska Airlines AS4378
19:23
John Glenn Columbus (CMH)

19:50
Chicago O'Hare (ORD) 3
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4299)
Duration: 1:27, non-stop
Embraer EMB 170 / EMB 175 (E70)
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This flight number is listed as serving the following routes:
  • Charleston (CHS) - Ronald Reagan Washington (DCA)
  • Chicago O'Hare (ORD) - Pittsburgh (PIT)
  • El Paso (ELP) - Chicago O'Hare (ORD)
  • Fayetteville/Springdale (XNA) - Los Angeles (LAX)
  • Flagstaff Pulliam, Grand Canyon (FLG) - Phoenix Sky Harbor (PHX)
  • George Bush, Houston (IAH) - Chicago O'Hare (ORD)
  • Grand Rapids (GRR) - Chicago O'Hare (ORD)
  • John Glenn Columbus (CMH) - Chicago O'Hare (ORD)
  • Kansas City (MCI) - Chicago O'Hare (ORD)
  • Knoxville (TYS) - Chicago O'Hare (ORD)
  • Los Angeles (LAX) - El Paso (ELP)
  • Memphis (MEM) - Philadelphia (PHL)
  • Moline (MLI) - Chicago O'Hare (ORD)
  • Oklahoma City (OKC) - Los Angeles (LAX)
  • Philadelphia (PHL) - Charleston (CHS)
  • Phoenix Sky Harbor (PHX) - Sacramento (SMF)
  • Pittsburgh (PIT) - Dallas Fort Worth (DFW)
  • Richmond (RIC) - Philadelphia (PHL)
  • Syracuse (SYR) - Ronald Reagan Washington (DCA)
All Alaska Airlines flights
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